Amelioration of portal hypertension and the hyperdynamic circulatory syndrome in cirrhotic rats by neuropeptide Y via pronounced splanchnic vasoaction
Publisher DOI
PubMed ID
21317421
Abstract
Splanchnic vasodilation triggers the development of the hyperdynamic circulatory syndrome in portal hypertension. Neuropeptide Y (NPY), a sympathetic co-transmitter of norepinephrine, improves contractility in mesenteric arteries of pre-hepatic portal hypertensive rats. Therefore, we investigated the effect of NPY on mesenteric arterial contractility in vitro and in vivo in cirrhotic ascitic rats, as well as the vasoactive pathways involved.
Date Issued
2011
Publication Type
Article
Language(s)
en
Author(s)
Moleda, Lukas | |
Trebicka, Jonel | |
Dietrich, Peter | |
Gäbele, Erwin | |
Hellerbrand, Claus | |
Straub, Rainer H | |
Sauerbruch, Tilman | |
Schoelmerich, Juergen |
Additional Credits
Journal
Gut
Publisher
BMJ Publishing Group
ISSN
0017-5749
Access(Rights)
metadata.only