Ion incorporation into bone grafting materials.
Publisher DOI
PubMed ID
37823468
Abstract
The use of biomaterials in regenerative medicine has expanded to treat various disorders caused by trauma or disease in orthopedics and dentistry. However, the treatment of large and complex bone defects presents a challenge, leading to a pressing need for optimized biomaterials for bone repair. Recent advances in chemical sciences have enabled the incorporation of therapeutic ions into bone grafts to enhance their performance. These ions, such as strontium (for bone regeneration/osteoporosis), copper (for angiogenesis), boron (for bone growth), iron (for chemotaxis), cobalt (for B12 synthesis), lithium (for osteogenesis/cementogenesis), silver (for antibacterial resistance), and magnesium (for bone and cartilage regeneration), among others (e.g., zinc, sodium, and silica), have been studied extensively. This review aims to provide a comprehensive overview of current knowledge and recent developments in ion incorporation into biomaterials for bone and periodontal tissue repair. It also discusses recently developed biomaterials from a basic design and clinical application perspective. Additionally, the review highlights the importance of precise ion introduction into biomaterials to address existing limitations and challenges in combination therapies. Future prospects and opportunities for the development and optimization of biomaterials for bone tissue engineering are emphasized.
Date Issued
2024-02
Publication Type
Article
Subject(s)
Subjects
biomaterials bone tissue engineering inorganic materials ion doping periodontal regeneration
Language(s)
en
Author(s)
Zhao, Qin | |
Ni, Yueqi | |
Wei, Hongjiang | |
Duan, Yiling | |
Chen, Jingqiu | |
Xiao, Qi | |
Gao, Jie | |
Yu, Yiqian | |
Cui, Yu | |
Ouyang, Simin | |
Zhang, Yufeng | |
Wu, Chengtie |
Additional Credits
Journal
Periodontology 2000
Publisher
Wiley
ISSN
1600-0757
Access(Rights)
restricted