Parkinsonism in Gaucher's disease type 1: ten new cases and a review of the literature
Publisher DOI
PubMed ID
19513999
Abstract
Parkinsonism has been described in patients with Gaucher's disease (GD). We reviewed the 10 cases of patients with both parkinsonism and GD recorded in the French national GD registry, as well as 49 previously published cases. Relative to the general population, parkinsonism in GD patients (1) was more frequent, (2) occurred at an earlier age, (3) responded less well to levodopa, and (4) was more frequently associated with signs of cortical dysfunction. Enzyme replacement therapy (ERT) and substrate reduction therapy (SRT) were ineffective on GD-associated parkinsonism, suggesting that parkinsonism itself is not an indication for ERT or SRT in this setting.
Date Issued
2009
Publication Type
Article
Language(s)
en
Author(s)
Kraoua, Ichraf | |
Stirnemann, Jérôme | |
Ribeiro, Maria João | |
Rouaud, Tiphaine | |
Verin, Marc | |
Annic, Agnès | |
Rose, Christian | |
Defebvre, Luc | |
Réménieras, Liliane | |
Belmatoug, Nadia | |
Vidailhet, Marie | |
Sedel, Frédéric |
Additional Credits
Journal
Movement disorders
Publisher
Wiley-Blackwell
ISSN
0885-3185
Access(Rights)
metadata.only