Publication:
How Do I Manage Refractory Invasive Pulmonary Aspergillosis.

cris.virtual.author-orcid0000-0002-7347-6312
cris.virtualsource.author-orcid12ab78c1-5475-4855-b0f7-4c90f05bc0ad
datacite.rightsopen.access
dc.contributor.authorVergidis, Paschalis
dc.contributor.authorSendi, Parham
dc.contributor.authorAlkhateeb, Hassan
dc.contributor.authorNguyen, M Hong
dc.date.accessioned2024-10-26T17:08:47Z
dc.date.available2024-10-26T17:08:47Z
dc.date.issued2024-06
dc.description.abstractBACKGROUND Invasive aspergillosis is associated with significant morbidity and mortality in patients with hematologic malignancies and hematopoietic cell transplant recipients. The prognosis is worse among patients who have failed primary antifungal treatment. OBJECTIVES We aim to provide guidance on the diagnosis and management of refractory invasive pulmonary aspergillosis. SOURCES Using PubMed we performed a review of original articles, meta-analyses, and systematic reviews. CONTENT We discuss the diagnostic criteria for invasive pulmonary aspergillosis and the evidence on treatment of primary infection. We outline our diagnostic approach to refractory disease. We propose a treatment algorithm for refractory disease and discuss the role of experimental antifungal agents. IMPLICATIONS For patients with worsening disease while on antifungal therapy, a thorough diagnostic evaluation is required to confirm the diagnosis of aspergillosis and exclude another concomitant infection. Treatment should be individualized. Current options include switching to another triazole, transitioning to a lipid formulation of amphotericin B, or using combination antifungal therapy.
dc.description.numberOfPages7
dc.description.sponsorshipInstitut für Infektionskrankheiten (IFIK) - Forschung
dc.identifier.doi10.48350/192237
dc.identifier.pmid38286175
dc.identifier.publisherDOI10.1016/j.cmi.2024.01.015
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/173875
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofClinical microbiology and infection
dc.relation.issn1469-0691
dc.relation.organizationDCD5A442BA19E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442BD12E17DE0405C82790C4DE2
dc.subjectAspergillosis Hematopoietic stem cell transplant Leukemia invasive fungal infection invasive mold infection refractory infection
dc.subject.ddc500 - Science::570 - Life sciences; biology
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleHow Do I Manage Refractory Invasive Pulmonary Aspergillosis.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage761
oaire.citation.issue6
oaire.citation.startPage755
oaire.citation.volume30
oairecerif.author.affiliationInstitut für Infektionskrankheiten (IFIK) - Forschung
oairecerif.author.affiliation2Institut für Infektionskrankheiten (IFIK)
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.date.embargoChanged2024-01-30 08:46:46
unibe.date.licenseChanged2024-01-30 08:55:54
unibe.description.ispublishedpub
unibe.eprints.legacyId192237
unibe.refereedtrue
unibe.subtype.articlereview

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