Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties.
Publisher DOI
PubMed ID
30252599
Abstract
Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier properties are comprised by a physical, a transport and a metabolic barrier, and all these barrier components play pivotal roles in the communication between saliva and blood. The sum of all epithelia of the oral cavity and salivary glands is defined as the blood-saliva barrier. The functionality of the barrier is regulated by its microenvironment and often altered during diseases. A huge array of cell culture models have been developed to mimic specific parts of the blood-saliva barrier, but no ultimate standard in vitro models have been established. This review provides a comprehensive overview about developed in vitro models of oral mucosal barriers, their applications, various cultivation protocols and corresponding barrier properties.
Date Issued
2018-09-25
Publication Type
Article
Subject(s)
Subjects
ABC-transporters SLC-transporter craniomaxillofacial surgery desmosomes gingivitis periodontitis saliva salivary gland tight junctions tongue
Language(s)
en
Author(s)
Bierbaumer, Lisa | |
Schwarze, Uwe Yacine | |
Neuhaus, Winfried |
Additional Credits
Journal
Tissue barriers
Publisher
Taylor & Francis
ISSN
2168-8370
Access(Rights)
restricted