Membrane Transporters: Solute Carriers
Abstract
Metabolic homeostasis within cells requires strict control over the import and export of metabolites, nutrients and ions across membranes. Polar chemical species such as these have negligible ability to cross phospholipid membranes by simple diffusion and instead require highly regulated transport proteins to control their movement. The largest class of transport proteins is the solute carrier (SLC) series (www.bioparadigms.org) and it is on this superfamily that this themed collection focuses.
These proteins are of great interest for basic academic research, but beyond that they are of central importance in a number of areas of applied science: as drug targets, as controllers of drug disposition and pharmacokinetics, and as the cause of drug toxicity.
This collection of articles, guest edited by Prof Matthias A. Hediger (University of Bern, Switzerland ) and & Dr David Hepworth (Pfizer) is a celebration of all areas of research where the chemical sciences have impacted the study of the SLC superfamily.
These proteins are of great interest for basic academic research, but beyond that they are of central importance in a number of areas of applied science: as drug targets, as controllers of drug disposition and pharmacokinetics, and as the cause of drug toxicity.
This collection of articles, guest edited by Prof Matthias A. Hediger (University of Bern, Switzerland ) and & Dr David Hepworth (Pfizer) is a celebration of all areas of research where the chemical sciences have impacted the study of the SLC superfamily.
Date Issued
2016
Publication Type
Editorship
Language(s)
en
Editor(s)
Additional Credits
Publisher
Royal Society of Chemistry
Access(Rights)
metadata.only