When mechanochemistry meets fluorine.
Publisher DOI
PubMed ID
41958289
Abstract
Given the importance of organofluorine compounds as potent pharmaceuticals, agrochemicals, and fine chemicals, there has been a surge in synthetic approaches to introduce fluoro/fluorinated functionalities into intact molecules. Among them, very few methods have been designed to align with one of the main principles of green chemistry, i.e., using solvent-free/low-solvent conditions. Mechanochemistry is a promising tool to fulfil this condition, offering many sustainable and energy-efficient alternatives compared to widely used conventional solution-based synthetic methods. In view of the importance of both organofluorine compounds and mechanochemistry, herein we present a feature article that summarizes the recent developments by our group and by a few others, in the form of a review, highlighting the role of mechanochemistry to access/upcycle/utilise the diverse array of (fluoro)organic compounds under mechanochemical conditions. Beyond the preparation of fluorinated molecules, a particular emphasis is placed on the utilisation in chemosynthesis of fluorinated additives, grinding auxiliaries, and fluorinated catalysts.
Date Issued
2026-04-30
Publication Type
Article
Language(s)
en
Author(s)
Purohit, Vishal B. | |
Prajapati, Ronak V. | |
Prajapati, Vaibhav D. | |
Mkrtchyan, Satenik |
Journal
Chemical Communications
Publisher
Royal Society of Chemistry
ISSN
1364-548X
1359-7345
Access(Rights)
restricted