Retrospective comparison of maternal vs. HPA-matched donor platelets for treatment of fetal alloimmune thrombocytopenia
Publisher DOI
PubMed ID
19874573
Abstract
In fetal alloimmune thrombocytopenia (FAIT), transplacental maternal antibodies cause destruction of fetal platelets. FAIT is similar to fetal Rhesus haemolytic disease, but half of the affected fetuses are born to primiparous women. In 10-20% of cases, prenatal and perinatal intracranial haemorrhages are reported. Different therapeutic approaches have been described, including maternally administered high-dose intravenous immunoglobulin (high dose IVIG) without or with steroids or intrauterine transfusion (IUT) of compatible platelets. For the latter, the use of plasma-free maternal and donor platelets has been described, but a comparison of these two sources of platelets has not been reported.
Date Issued
2010
Publication Type
Article
Language(s)
en
Author(s)
Giers, G | |
Wenzel, F | |
Fischer, J | |
Stockschläder, M | |
Riethmacher, R | |
Lorenz, H |
Additional Credits
Journal
Vox sanguinis
Publisher
Wiley-Blackwell
ISSN
0042-9007
Access(Rights)
metadata.only