DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH

PubMed ID
21703208
Description
Intestinal bacterial overgrowth and increased permeability are features of non alcoholic steatohepatitis (NASH). Bacterial endotoxin has been shown to promote NASH progression. Application of dextran sulfate sodium (DSS) is a colitis model in mice characterized by damage of the intestinal barrier. This study was designed to investigate if application of DSS aggravates experimental NASH.
Date of Publication
2011
Publication Type
Article
Language(s)
en
Contributor(s)
Gäbele, Erwin
Dostert, Karin
Hofmann, Claudia
Schölmerich, Jürgen
Hellerbrand, Claus
Obermeier, Florian
Additional Credits
Series
Journal of hepatology
Publisher
Elsevier
ISSN
0168-8278
Access(Rights)
metadata.only
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