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Nature and Nurture: Brain Region-Specific Inheritance of Sleep Neurophysiology in Adolescence

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cris.virtual.author-orcid0000-0002-2369-5920
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cris.virtual.author-orcid0000-0003-4014-428X
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cris.virtualsource.author-orcid998864db-20ca-4a53-8a70-937efcb9e38e
cris.virtualsource.author-orcidc44e2e04-d2b0-45e4-9312-85f4a1c80c63
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cris.virtualsource.author-orcid681b0e81-83ac-46da-9f9b-6a3f7e1aadff
dc.contributor.authorRusterholz, Thomas
dc.contributor.authorHamann, Christoph
dc.contributor.authorMarkovic, Andjela
dc.contributor.authorSchmidt, Stefanie Julia
dc.contributor.authorAchermann, Peter
dc.contributor.authorTarokh, Leila
dc.date.accessioned2024-10-07T16:34:56Z
dc.date.available2024-10-07T16:34:56Z
dc.date.issued2018
dc.description.abstractSleep-specific oscillations of spindles and slow waves are generated through thalamocortical and corticocortical loops, respectively, and provide a unique opportunity to measure the integrity of these neuronal systems. Understanding the relative contribution of genetic factors to sleep oscillations is important for determining whether they constitute useful endophenotypes that mark vulnerability to psychiatric illness. Using high-density sleep EEG recordings in human adolescent twin pairs (n = 60; 28 females), we find that over posterior regions 80-90% of the variance in slow oscillations, slow wave, and spindle activity is due to genes. Surprisingly, slow (10-12 Hz) and fast (12-16 Hz) anterior spindle amplitude and σ power are largely driven by environmental factors shared among the twins. To our knowledge this is the first example of a neural phenotype that exhibits a strong influence of nature in one brain region, and nurture in another. Overall, our findings highlight the utility of the sleep EEG as a reliable and easy to measure endophenotype during adolescence. This measure may be used to measure disease risk in development before the onset of a psychiatric disorder; the location within the brain of deficits in sleep neurophysiology may suggest whether the ultimate cause is genetic or environmental. SIGNIFICANCE STATEMENT Two cardinal oscillations of sleep, slow waves and sleep spindles, play an important role in the core functions of sleep including memory consolidation, synaptic plasticity, and the recuperative function of sleep. In this study, we use a behavioral genetics approach to examine the heritability of sleep neurophysiology using high-density EEG in a sample of early adolescent twins. Our findings reveal a strong influence of both environmental and genetic factors in shaping these oscillations, dependent on brain region. Thus, during a developmental period when brain structure and function is in flux, we find that the sleep EEG is among the most heritable of human traits over circumscribed brain regions.
dc.description.numberOfPages11
dc.description.sponsorshipUniversitätsklinik für Kinder- und Jugendpsychiatrie und Psychotherapie (KJP)
dc.description.sponsorshipInstitut für Psychologie, Klinische Psychologie und Psychotherapie
dc.identifier.doi10.7892/boris.121256
dc.identifier.pmid30249805
dc.identifier.publisherDOI10.1523/JNEUROSCI.0945-18.2018
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/60610
dc.language.isoen
dc.publisherSociety for Neuroscience
dc.relation.ispartofJournal of neuroscience
dc.relation.issn0270-6474
dc.relation.organizationDCD5A442BA84E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442BA50E17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.subject.ddc100 - Philosophy::150 - Psychology
dc.titleNature and Nurture: Brain Region-Specific Inheritance of Sleep Neurophysiology in Adolescence
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage9285
oaire.citation.issue43
oaire.citation.startPage9275
oaire.citation.volume38
oairecerif.author.affiliationUniversitätsklinik für Kinder- und Jugendpsychiatrie und Psychotherapie (KJP)
oairecerif.author.affiliationUniversitätsklinik für Kinder- und Jugendpsychiatrie und Psychotherapie (KJP)
oairecerif.author.affiliationUniversitätsklinik für Kinder- und Jugendpsychiatrie und Psychotherapie (KJP)
oairecerif.author.affiliationInstitut für Psychologie, Klinische Psychologie und Psychotherapie
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oairecerif.author.affiliationUniversitätsklinik für Kinder- und Jugendpsychiatrie und Psychotherapie (KJP)
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oairecerif.author.affiliation2Universitätsklinik für Kinder- und Jugendpsychiatrie und Psychotherapie (KJP)
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unibe.date.embargoChanged2019-04-25 00:30:05
unibe.date.licenseChanged2019-10-23 16:28:30
unibe.description.ispublishedpub
unibe.eprints.legacyId121256
unibe.journal.abbrevTitleJ NEUROSCI
unibe.refereedTRUE
unibe.subtype.articlejournal

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