Beyond keratinocyte differentiation: emerging new biology of small proline-rich proteins.

BORIS DOI
Publisher DOI
PubMed ID
36057494
Description
Small proline-rich proteins (SPRRPs) are traditionally known for their function in keratinocyte homeostasis. Recent evidence demonstrates their involvement in additional diverse physiological processes ranging from p53 signaling and direct prevention of DNA damage to bactericidal activities. We highlight these novel, intriguing roles of SPRRPs and discuss them in the context of relevant pathological conditions.
Date of Publication
2023-01
Publication Type
Article
Subject(s)
Keyword(s)
DNA damage protection bactericidal activity cornified cell envelope epithelial tissue defense p53 signaling reactive oxygen species small proline-rich proteins
Language(s)
en
Contributor(s)
Additional Credits
Series
Trends in cell biology
Publisher
Elsevier
ISSN
1879-3088
Access(Rights)
open.access
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