Functional Association between Regulatory RNAs and the Annexins.
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BORIS DOI
Date of Publication
February 16, 2018
Publication Type
Article
Division/Institute
Subject(s)
Series
International journal of molecular sciences
ISSN or ISBN (if monograph)
1661-6596
Publisher
MDPI
Language
English
Publisher DOI
PubMed ID
29462943
Uncontrolled Keywords
Description
Cells respond to pathophysiological states by activation of stress-induced signalling. Regulatory non-coding microRNAs (miRNAs) often form stable feed-forward loops which ensure prolongation of the signal, contributing to sustained activation. Members of the annexin protein family act as sensors for Ca, pH, and lipid second messengers, and regulate various signalling pathways. Recently, annexins were reported to participate in feedback loops, suppressing miRNA synthesis and attenuating stress-induced dysregulation of gene expression. They can directly or indirectly associate with RNAs, and are transferred between the cells in exosomes and shed microvesicles. The ability of annexins to recruit other proteins and miRNAs into exosomes implicates them in control of cell-cell interactions, affecting the adaptive responses and remodelling processes during disease. The studies summarized in this Review point to an emerging role of annexins in influencing the synthesis, localisation, and transfer of regulatory RNAs.
File(s)
File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
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ijms-19-00591-v2.pdf | text | Adobe PDF | 2.39 MB | published |