Molecular definitions of autophagy and related processes.

DOI
Publisher DOI
PubMed ID
28596378
Abstract
Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.
Date Issued
2017-07-03
Publication Type
Article
Subject(s)
Subjects
LC3‐associated phagocytosis chaperone‐mediated autophagy microautophagy mitophagy xenophagy
Language(s)
en
Author(s)
Galluzzi, Lorenzo
Baehrecke, Eric H
Ballabio, Andrea
Boya, Patricia
Bravo-San Pedro, José Manuel
Cecconi, Francesco
Choi, Augustine M
Chu, Charleen T
Codogno, Patrice
Colombo, Maria Isabel
Cuervo, Ana Maria
Debnath, Jayanta
Deretic, Vojo
Dikic, Ivan
Eskelinen, Eeva-Liisa
Fimia, Gian Maria
Fulda, Simone
Gewirtz, David A
Green, Douglas R
Hansen, Malene
Harper, J Wade
Jäättelä, Marja
Johansen, Terje
Juhasz, Gabor
Kimmelman, Alec C
Kraft, Claudine
Ktistakis, Nicholas T
Kumar, Sharad
Levine, Beth
Lopez-Otin, Carlos
Madeo, Frank
Martens, Sascha
Martinez, Jennifer
Melendez, Alicia
Mizushima, Noboru
Münz, Christian
Murphy, Leon O
Penninger, Josef M
Piacentini, Mauro
Reggiori, Fulvio
Rubinsztein, David C
Ryan, Kevin M
Santambrogio, Laura
Scorrano, Luca
Simon, Anna Katharina
Simonsen, Anne
Tavernarakis, Nektarios
Tooze, Sharon A
Yoshimori, Tamotsu
Yuan, Junying
Yue, Zhenyu
Zhong, Qing
Kroemer, Guido
Additional Credits
Journal
The EMBO Journal
Publisher
EMBO Press
ISSN
1460-2075
Access(Rights)
restricted
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