Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus.
Publisher DOI
PubMed ID
29037765
Abstract
The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.
Date Issued
2018-01
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Spindler, Volker | |
Eming, Rüdiger | |
Schmidt, Enno | |
Amagai, Masayuki | |
Grando, Sergei | |
Jonkman, Marcel F | |
Kowalczyk, Andrew P | |
Payne, Aimee S | |
Pincelli, Carlo | |
Sinha, Animesh A | |
Sprecher, Eli | |
Zillikens, Detlef | |
Hertl, Michael | |
Waschke, Jens |
Additional Credits
Journal
Journal of Investigative Dermatology
Publisher
Nature Publishing
ISSN
0022-202X
Access(Rights)
restricted