Publication:
A disease model for wheezing disorders in preschool children based on clinicians' perceptions

cris.virtual.author-orcid0000-0002-1430-5695
cris.virtualsource.author-orcid6e25de3f-9b4e-4488-b08e-d11851e4161e
cris.virtualsource.author-orcid3857e2d3-2b7f-42b6-878d-ce868ac1673c
datacite.rightsopen.access
dc.contributor.authorSpycher, Ben
dc.contributor.authorSilverman, Michael
dc.contributor.authorBarben, Juerg
dc.contributor.authorEber, Ernst
dc.contributor.authorGuinand, Stéphane
dc.contributor.authorLevy, Mark L
dc.contributor.authorPao, Caroline
dc.contributor.authorvan Aalderen, Willem M
dc.contributor.authorvan Schayck, Onno C P
dc.contributor.authorKühni, Claudia
dc.date.accessioned2024-10-14T07:31:42Z
dc.date.available2024-10-14T07:31:42Z
dc.date.issued2009
dc.description.abstractBACKGROUND: Wheezing disorders in childhood vary widely in clinical presentation and disease course. During the last years, several ways to classify wheezing children into different disease phenotypes have been proposed and are increasingly used for clinical guidance, but validation of these hypothetical entities is difficult. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this study was to develop a testable disease model which reflects the full spectrum of wheezing illness in preschool children. We performed a qualitative study among a panel of 7 experienced clinicians from 4 European countries working in primary, secondary and tertiary paediatric care. In a series of questionnaire surveys and structured discussions, we found a general consensus that preschool wheezing disorders consist of several phenotypes, with a great heterogeneity of specific disease concepts between clinicians. Initially, 24 disease entities were described among the 7 physicians. In structured discussions, these could be narrowed down to three entities which were linked to proposed mechanisms: a) allergic wheeze, b) non-allergic wheeze due to structural airway narrowing and c) non-allergic wheeze due to increased immune response to viral infections. This disease model will serve to create an artificial dataset that allows the validation of data-driven multidimensional methods, such as cluster analysis, which have been proposed for identification of wheezing phenotypes in children. CONCLUSIONS/SIGNIFICANCE: While there appears to be wide agreement among clinicians that wheezing disorders consist of several diseases, there is less agreement regarding their number and nature. A great diversity of disease concepts exist but a unified phenotype classification reflecting underlying disease mechanisms is lacking. We propose a disease model which may help guide future research so that proposed mechanisms are measured at the right time and their role in disease heterogeneity can be studied.
dc.description.numberOfPages7
dc.description.sponsorshipInstitut für Sozial- und Präventivmedizin (ISPM)
dc.identifier.doi10.7892/boris.30352
dc.identifier.isi000273180200014
dc.identifier.pmid20046874
dc.identifier.publisherDOI10.1371/journal.pone.0008533
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/103868
dc.language.isoen
dc.publisherPublic Library of Science
dc.publisher.placeLawrence, Kans.
dc.relation.isbn20046874
dc.relation.ispartofPLoS ONE
dc.relation.issn1932-6203
dc.relation.organizationDCD5A442BECFE17DE0405C82790C4DE2
dc.titleA disease model for wheezing disorders in preschool children based on clinicians' perceptions
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue12
oaire.citation.startPagee8533
oaire.citation.volume4
oairecerif.author.affiliationInstitut für Sozial- und Präventivmedizin (ISPM)
oairecerif.author.affiliationInstitut für Sozial- und Präventivmedizin (ISPM)
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unibe.description.ispublishedpub
unibe.eprints.legacyId30352
unibe.journal.abbrevTitlePLOS ONE
unibe.refereedtrue
unibe.subtype.articlejournal

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