Publication:
Regional Disconnection in Alzheimer Dementia and Amyloid-Positive Mild Cognitive Impairment: Association Between EEG Functional Connectivity and Brain Glucose Metabolism.

cris.virtual.author-orcid0000-0002-1472-4638
cris.virtualsource.author-orcid7a31d195-a565-4659-9ab7-18490b97cee5
dc.contributor.authorSmailovic, Una
dc.contributor.authorKönig, Thomas
dc.contributor.authorSavitcheva, Irina
dc.contributor.authorChiotis, Konstantinos
dc.contributor.authorNordberg, Agneta
dc.contributor.authorBlennow, Kaj
dc.contributor.authorWinblad, Bengt
dc.contributor.authorJelic, Vesna
dc.date.accessioned2024-09-02T16:31:34Z
dc.date.available2024-09-02T16:31:34Z
dc.date.issued2020-11-23
dc.description.abstractIntroduction: The disconnection hypothesis of Alzheimer's disease (AD) is supported by growing neuroimaging and neurophysiological evidence of altered brain functional connectivity in cognitively impaired individuals. Brain functional modalities such as [18F]fluorodeoxyglucose positron-emission tomography ([18F]FDG-PET) and electroencephalography (EEG) measure different aspects of synaptic functioning, and can contribute to understanding brain connectivity disruptions in AD. Aim: This study investigated the relationship between cortical glucose metabolism and topographical EEG measures of brain functional connectivity in subjects along AD continuum. Methods: Patients diagnosed with mild cognitive impairment (MCI) and AD (n = 67), and stratified into amyloid-positive (n = 32) and negative (n = 10) groups according to cerebrospinal fluid Aβ42/40 ratio, were assessed with [18F]FDG-PET and resting-state EEG recordings. EEG-based neuroimaging analysis involved standardized low-resolution electromagnetic tomography (sLORETA), which estimates functional connectivity from cortical sources of electrical activity in a 3D head model. Results: Glucose hypometabolism in temporoparietal lobes was significantly associated with altered EEG functional connectivity of the same regions of interest in clinically diagnosed MCI and AD patients and in patients with biomarker-verified AD pathology. The correlative pattern of disrupted connectivity in temporoparietal lobes, as detected by EEG sLORETA analysis, included decreased instantaneous linear connectivity in fast frequencies and increased lagged linear connectivity in slow frequencies in relation to the activity of remaining cortex. Conclusions: Topographical EEG measures of functional connectivity detect regional dysfunction of AD-vulnerable brain areas as evidenced by association and spatial overlap with the cortical glucose hypometabolism in MCI and AD patients. Impact statement The association between glucose hypometabolism, as evidenced by [18F]FDG-PET ([18F]fluorodeoxyglucose positron-emission tomography), and altered electroencephalography (EEG) functional connectivity metrics within temporoparietal lobes provides link between synaptic, neurophysiological, and metabolic impairment in mild cognitive impairment and Alzheimer's disease patients. This study reported alterations in EEG measures of both instantaneous and lagged linear connectivity across distinct frequency bands, both of which were shown to be important for inter- and intrahemispheric communication and function of memory systems in general. EEG-based imaging of brain functional connectivity has a potential to serve as a noninvasive, low-cost, and widely available alternative in assessing synaptic and network dysfunction in cognitively impaired patients.
dc.description.numberOfPages11
dc.description.sponsorshipZentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
dc.identifier.doi10.48350/148866
dc.identifier.pmid33073602
dc.identifier.publisherDOI10.1089/brain.2020.0785
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/38321
dc.language.isoen
dc.publisherMary Ann Liebert
dc.relation.ispartofBrain connectivity
dc.relation.issn2158-0014
dc.relation.organization33BF865BF1D23C90E053960C5C8246BD
dc.subjectAlzheimer's disease [18F]fluorodeoxyglucose-PET electroencephalography functional connectivity standardized low-resolution electromagnetic tomography (sLORETA)
dc.titleRegional Disconnection in Alzheimer Dementia and Amyloid-Positive Mild Cognitive Impairment: Association Between EEG Functional Connectivity and Brain Glucose Metabolism.
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage565
oaire.citation.issue10
oaire.citation.startPage555
oaire.citation.volume10
oairecerif.author.affiliationZentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
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unibe.date.licenseChanged2020-12-29 12:39:57
unibe.description.ispublishedpub
unibe.eprints.legacyId148866
unibe.journal.abbrevTitleBrain Connect
unibe.refereedTRUE
unibe.subtype.articlejournal

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