Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome

Publisher DOI
PubMed ID
21115979
Abstract
Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.
Date Issued
2011
Publication Type
Article
Language(s)
en
Author(s)
Rinaldi, Andrea
Mian, Michael
Chigrinova, Ekaterina
Arcaini, Luca
Bhagat, Govind
Rancoita, Paola M. V.
De Campos, Cassio P.
Forconi, Francesco
Gascoyne, Randy D.
Facchetti, Fabio
Ponzoni, Maurilio
Govi, Silvia
Ferreri, Andrés J. M.
Mollejo, Manuela
Piris, Miguel A.
Baldini, Luca
Soulier, Jean
Thieblemont, Catherine
Canzonieri, Vincenzo
Gattei, Valter
Marasca, Roberto
Franceschetti, Silvia
Gaidano, Gianluca
Tucci, Alessandra
Uccella, Silvia
Tibiletti, Maria Grazia
Dirnhofer, Stephan
Tripodo, Claudio
Doglioni, Claudio
Dalla Favera, Riccardo
Cavalli, Franco
Zucca, Emanuele
Kwee, Ivo
Bertoni, Francesco
Additional Credits
Journal
Blood
Publisher
American Society of Hematology
ISSN
0006-4971
Access(Rights)
metadata.only
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