Towards a complete map of the human long non-coding RNA transcriptome.
Publisher DOI
PubMed ID
29795125
Abstract
Gene maps, or annotations, enable us to navigate the functional landscape of our genome. They are a resource upon which virtually all studies depend, from single-gene to genome-wide scales and from basic molecular biology to medical genetics. Yet present-day annotations suffer from trade-offs between quality and size, with serious but often unappreciated consequences for downstream studies. This is particularly true for long non-coding RNAs (lncRNAs), which are poorly characterized compared to protein-coding genes. Long-read sequencing technologies promise to improve current annotations, paving the way towards a complete annotation of lncRNAs expressed throughout a human lifetime.
Date Issued
2018-09
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Uszczynska-Ratajczak, Barbara | |
Lagarde, Julien | |
Frankish, Adam | |
Guigó, Roderic |
Additional Credits
Journal
Nature Reviews. Genetics
Publisher
Natue Publishing Group
ISSN
1471-0056
Access(Rights)
restricted