Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)
Publisher DOI
PubMed ID
17562801
Abstract
Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.
Date Issued
2007
Publication Type
Article
Language(s)
en
Author(s)
Kaiser, Marcel | |
Wittlin, Sergio | |
Nehrbass-Stuedli, Angela | |
Dong, Yuxiang | |
Wang, Xiaofang | |
Matile, Hugues | |
Brun, Reto | |
Vennerstrom, Jonathan L |
Additional Credits
Journal
Antimicrobial agents and chemotherapy
Publisher
American Society for Microbiology
ISSN
0066-4804
Access(Rights)
metadata.only