Cerebral disconnectivity: an early event in schizophrenia
Publisher DOI
PubMed ID
17911212
Abstract
Neuroimaging and electrophysiological investigations have demonstrated numerous differences in brain morphology and function of chronic schizophrenia patients compared to healthy controls. Studying patients at the beginning of their disease without the confounding effects of chronicity, medication, and institutionalization may provide a better understanding of schizophrenia. Recently, at many institutions around the world, special projects have been launched for specialized treatment and research of this interesting patient group. Using the PubMed search engine in this update, the authors summarize recent investigations between January 2002 and September 2006 that focus on whether signs of disconnectivity already exist early in the disease process. They discuss gray and white matter changes, their impact on symptomatology, electroencephalogram-based studies on connectivity, and possible influences of medication.
Date Issued
2008
Publication Type
Article
Language(s)
en
Journal
Neuroscientist
Publisher
Sage Publications
ISSN
1073-8584
ISBN
17911212
Access(Rights)
restricted