Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation.
Publisher DOI
PubMed ID
33917629
Abstract
Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. Finally we review approaches to rational antigen selection and rational vaccine adjuvant design. Harnessing current knowledge on protective immune responses in combination with critical vaccine components is imperative to the prevention of future life-threatening diseases.
Date Issued
2021-04-06
Publication Type
Article
Subjects
adjuvant antigen delivery system design immunization rational route vaccine
Language(s)
en
Author(s)
Schijns, Virgil | |
Majhen, Dragomira | |
van der Ley, Peter | |
Thakur, Aneesh | |
Berisio, Rita | |
Nativi, Cristina | |
Fernández-Tejada, Alberto | |
Alvarez-Dominguez, Carmen | |
Gizurarson, Sveinbjörn | |
Zamyatina, Alla | |
Molinaro, Antonio | |
Rosano, Camillo | |
Jakopin, Žiga | |
Gursel, Ihsan | |
McClean, Siobhán |
Journal
Pharmaceutics
Publisher
MDPI
ISSN
1999-4923
Access(Rights)
open.access