New cycloartane-type ester triterpenes from Euphorbia pterococca and biological evaluation.
Publisher DOI
PubMed ID
29524564
Abstract
From acetonic extract of the whole plant Euphorbia pterococca Brot. (Euphorbiaceae), four new cycloartane-type ester triterpenes named cycloartenyl-2'E,4'E-decadienoate (1), cycloartenyl-2'E,4'Z-decadienoate (2), 24-methylenecycloartanyl-2'E,4'Z-tetradecadienoate (3), and 24-oxo-29-norcycloartanyl-2'E,4'Z-hexadecadienoate (4) were obtained along with nine known tetracyclic triterpenes (5-13). Their structures were established mainly by extensive use of spectroscopic techniques, including 1D (H and C) and 2D homo- and heteronuclear NMR experiments (COSY, HSQC, HMBC and NOESY), and mass spectrometry (HRESIMS), and by comparison with data reported in the literature. In addition, the new compounds 1-3 have been tested for cytotoxicity, trypanocidal effects and on enzymes involved in endocannabinoid degradation. While inactive in all assays up to 100 μM, 1 showed selective inhibition of α/β-hydrolase 12 with an IC of 11.6 ± 1.9 μM.
Date Issued
2018-06
Publication Type
Article
Subjects
Alpha/beta hydrolase-12 Cycloartanes Euphorbia pterococca Euphorbiaceae NMR Triterpenoids
Language(s)
en
Author(s)
Benabdelaziz, Imane | |
Gómez-Ruiz, Santiago | |
Benkhaled, Mohammed | |
Carralero, Sandra | |
Haba, Hamada |
Additional Credits
Journal
Fitoterapia
Publisher
Elsevier Science
ISSN
0367-326X
Access(Rights)
restricted