Within-breath changes in respiratory system impedance in children with cystic fibrosis.
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BORIS DOI
Publisher DOI
PubMed ID
30828997
Description
BACKGROUND
The aim of this study was to assess within-breath respiratory system impedance by the forced oscillation technique (FOT) in children with cystic fibrosis (CF) and relate it to the underlying lung disease.
METHODS
Thirty-three children with CF (median [range] age 12.0 [6-17] years) underwent FOT at 8 Hz during tidal breathing, multiple breath nitrogen washout (LCI), spirometry (FEV1), body plethysmography (RV/TLC), and magnetic resonance imaging (MRI). FOT outcomes included: mean inspiratory, expiratory, and whole breath resistance (R8 , R8 , R8 ) and reactance (X8 , X8 , X8 ), and the differences between X8 and X8 (ΔX8). Morphological changes were evaluated by MRI using CF-specific morphological scores. Spearman correlation was performed to examine the correlation between FOT indices and other parameters.
RESULTS
FEV1 was negatively correlated with R8 (r = -0.52, P = 0.002) and ΔX8 (r = -0.55, P = 0.001), and positively correlated with and X8 (r = 0.56, P < 0.001). RV/TLC was positively correlated with R8 (r = 0.43, P = 0.013), and ΔX8 (r = 0.54, P = 0.001) and negatively correlated with X8 (r = -0.54, P = 0.001). We found poor correlation between FOT parameters and LCI and no correlation between FOT parameters and MRI scores.
CONCLUSION
In children with CF, changes in within-breath FOT parameters are consistent with peripheral obstruction and dynamic airway compression, while they are not associated with ventilation heterogeneities and morphological alterations.
The aim of this study was to assess within-breath respiratory system impedance by the forced oscillation technique (FOT) in children with cystic fibrosis (CF) and relate it to the underlying lung disease.
METHODS
Thirty-three children with CF (median [range] age 12.0 [6-17] years) underwent FOT at 8 Hz during tidal breathing, multiple breath nitrogen washout (LCI), spirometry (FEV1), body plethysmography (RV/TLC), and magnetic resonance imaging (MRI). FOT outcomes included: mean inspiratory, expiratory, and whole breath resistance (R8 , R8 , R8 ) and reactance (X8 , X8 , X8 ), and the differences between X8 and X8 (ΔX8). Morphological changes were evaluated by MRI using CF-specific morphological scores. Spearman correlation was performed to examine the correlation between FOT indices and other parameters.
RESULTS
FEV1 was negatively correlated with R8 (r = -0.52, P = 0.002) and ΔX8 (r = -0.55, P = 0.001), and positively correlated with and X8 (r = 0.56, P < 0.001). RV/TLC was positively correlated with R8 (r = 0.43, P = 0.013), and ΔX8 (r = 0.54, P = 0.001) and negatively correlated with X8 (r = -0.54, P = 0.001). We found poor correlation between FOT parameters and LCI and no correlation between FOT parameters and MRI scores.
CONCLUSION
In children with CF, changes in within-breath FOT parameters are consistent with peripheral obstruction and dynamic airway compression, while they are not associated with ventilation heterogeneities and morphological alterations.
Date of Publication
2019-06
Publication Type
Article
Subject(s)
Keyword(s)
cystic fibrosis respiratory system impedance within-breath forced oscillation technique
Language(s)
en
Contributor(s)
Series
Pediatric pulmonology
Publisher
Wiley-Blackwell
ISSN
8755-6863
Access(Rights)
restricted