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Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study

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cris.virtual.author-orcid0000-0001-5297-6062
cris.virtualsource.author-orcid91a3060c-0e74-4217-944d-3471766e2083
datacite.rightsopen.access
dc.contributor.authorRauch, Andri
dc.contributor.authorNolan, D
dc.contributor.authorMartin, A
dc.contributor.authorMcKinnon, E
dc.contributor.authorAlmeida, C
dc.contributor.authorMallal, Simon
dc.date.accessioned2024-10-13T13:37:58Z
dc.date.available2024-10-13T13:37:58Z
dc.date.issued2006
dc.description.abstractAbacavir therapy is associated with significant drug hypersensitivity in approximately 8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allele. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipients.
dc.description.numberOfPages4
dc.description.sponsorshipUniversitätsklinik für Infektiologie
dc.identifier.doi10.7892/boris.19240
dc.identifier.isi000238030000015
dc.identifier.pmid16758424
dc.identifier.publisherDOI10.1086/504874
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/93006
dc.language.isoen
dc.publisherThe University of Chicago Press
dc.publisher.placeCary, N.C.
dc.relation.isbn16758424
dc.relation.ispartofClinical infectious diseases
dc.relation.issn1058-4838
dc.relation.organizationDCD5A442BB13E17DE0405C82790C4DE2
dc.titleProspective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage102
oaire.citation.issue1
oaire.citation.startPage99
oaire.citation.volume43
oairecerif.author.affiliationUniversitätsklinik für Infektiologie
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unibe.date.licenseChanged2019-10-31 14:16:50
unibe.description.ispublishedpub
unibe.eprints.legacyId19240
unibe.journal.abbrevTitleCLIN INFECT DIS
unibe.refereedtrue
unibe.subtype.articlejournal

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