Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study).

BORIS DOI
Publisher DOI
PubMed ID
37346094
Description
The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction.
Date of Publication
2023-06
Publication Type
Article
Subject(s)
Keyword(s)
Covid‐19 breakthrough infection health professionals symptoms vaccine
Language(s)
en
Contributor(s)
Kohler, Philipp
Babouee Flury, Baharak
Güsewell, Sabine
Egger, Thomas
Leal, Onicio
Brucher, Angela
Lemmenmeier, Eva
Meier Kleeb, Dorette
Möller, J Carsten
Ortner, Manuela
Rieder, Philip
Ruetti, Markus
Schmid, Hans-Ruedi
Stocker, Reto
Vuichard-Gysin, Danielle
Speer, Oliver
Wiggli, Benedikt
Besold, Ulrike
McGeer, Allison
Friedl, Andrée
Schlegel, Matthias
Vernazza, Pietro
Kahlert, Christian R
Kuster, Stefan P
Additional Credits
Series
Influenza and other respiratory viruses
Publisher
Wiley
ISSN
1750-2659
Access(Rights)
open.access
Show full item