A unification of models for meta-analysis of diagnostic accuracy studies
Publisher DOI
PubMed ID
16698768
Abstract
Studies of diagnostic accuracy require more sophisticated methods for their meta-analysis than studies of therapeutic interventions. A number of different, and apparently divergent, methods for meta-analysis of diagnostic studies have been proposed, including two alternative approaches that are statistically rigorous and allow for between-study variability: the hierarchical summary receiver operating characteristic (ROC) model (Rutter and Gatsonis, 2001) and bivariate random-effects meta-analysis (van Houwelingen and others, 1993), (van Houwelingen and others, 2002), (Reitsma and others, 2005). We show that these two models are very closely related, and define the circumstances in which they are identical. We discuss the different forms of summary model output suggested by the two approaches, including summary ROC curves, summary points, confidence regions, and prediction regions.
Date Issued
2007
Publication Type
Article
Language(s)
en
Author(s)
Harbord, Roger M | |
Deeks, Jonathan J | |
Whiting, Penny | |
Sterne, Jonathan A C |
Additional Credits
Journal
Biostatistics
Publisher
Oxford University Press
ISSN
1465-4644
ISBN
16698768
Access(Rights)
restricted