Publication:
The annexins: spatial and temporal coordination of signaling events during cellular stress

cris.virtualsource.author-orcid083943e3-ae7a-4391-91d3-91bed86ab50e
datacite.rightsopen.access
dc.contributor.authorMonastyrskaya, Katia
dc.contributor.authorBabiichuk, Eduard
dc.contributor.authorDraeger, Annette
dc.date.accessioned2024-10-14T07:39:50Z
dc.date.available2024-10-14T07:39:50Z
dc.date.issued2009
dc.description.abstractAnnexins are a family of structurally related, Ca2+-sensitive proteins that bind to negatively charged phospholipids and establish specific interactions with other lipids and lipid microdomains. They are present in all eukaryotic cells and share a common folding motif, the "annexin core", which incorporates Ca2+- and membrane-binding sites. Annexins participate in a variety of intracellular processes, ranging from the regulation of membrane dynamics to cell migration, proliferation, and apoptosis. Here we focus on the role of annexins in cellular signaling during stress. A chronic stress response triggers the activation of different intracellular pathways, resulting in profound changes in Ca2+ and pH homeostasis and the production of lipid second messengers. We review the latest data on how these changes are sensed by the annexins, which have the ability to simultaneously interact with specific lipid and protein moieties at the plasma membrane, contributing to stress adaptation via regulation of various signaling pathways.
dc.description.numberOfPages20
dc.description.sponsorshipInstitut für Anatomie, Zellbiologie
dc.identifier.doi10.7892/boris.31089
dc.identifier.isi000268295100002
dc.identifier.pmid19381436
dc.identifier.publisherDOI10.1007/s00018-009-0027-1
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/104557
dc.language.isoen
dc.publisherSP Birkhäuser Verlag Basel
dc.publisher.placeBasel
dc.relation.ispartofCellular and molecular life sciences
dc.relation.issn1420-682X
dc.relation.organizationDCD5A442BD6DE17DE0405C82790C4DE2
dc.titleThe annexins: spatial and temporal coordination of signaling events during cellular stress
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage42
oaire.citation.issue16
oaire.citation.startPage2623
oaire.citation.volume66
oairecerif.author.affiliationInstitut für Anatomie, Zellbiologie
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.date.licenseChanged2019-10-22 18:44:39
unibe.description.ispublishedpub
unibe.eprints.legacyId31089
unibe.journal.abbrevTitleCELL MOL LIFE SCI
unibe.refereedtrue
unibe.subtype.articlecontribution

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