Incidence and outcome of invasive fungal diseases after allogeneic hematopoietic stem cell transplantation: A Swiss transplant cohort study.
Publisher DOI
PubMed ID
30144374
Abstract
Contemporary, comprehensive data on epidemiology and outcomes of invasive fungal disease (IFD) including breakthrough IFD among allogeneic hematopoietic stem cell transplantation (HSCT) recipients are scarce. We included 479 allogeneic HSCT recipients with 10 invasive candidiasis (IC) and 31 probable/proven invasive mold disease (IMD) from the Swiss Transplant Cohort Study from 01.2009 to 08.2013. Overall cumulative incidence was 2.3% for IC and 8.5% for probable/proven IMI: 6% for invasive aspergillosis (IA) and 2.5% for non-AspergillusIMI. Among 41 IFD, 46% IFD were breakthrough, with an overall incidence of 4.6%, more frequently caused by other-than-Aspergillus fumigatus molds than primary IFD (47.6% (10/21) vs 13% (3/23), P = 0.04). Twelve-week mortality among patients with IC was 20% and 58.6% for probable/proven IMD (60% IA and 54.6% non-Aspergillus). Our results reveal that breakthrough IFD represent a marked burden of probable/proven IFD postallogeneic HSCT and mortality remains above 50% in patients with probable/proven IMD, underscoring the ongoing challenges to prevent and treat IFD in these patients.
Date Issued
2018-12
Publication Type
Article
Subject(s)
Subjects
breakthrough infections hematopoietic stem cell transplantation invasive fungal diseases invasive mold disease
Language(s)
en
Author(s)
Kuster, Sabine | |
Stampf, Susanne | |
Gerber, Bernhard | |
Baettig, Veronika | |
Weisser, Maja | |
Gerull, Sabine | |
Medinger, Michael | |
Passweg, Jakob | |
Schanz, Urs | |
Berger, Christoph | |
Chalandon, Yves | |
Mueller, Nicolas J | |
van Delden, Christian | |
Neofytos, Dionysios | |
Khanna, Nina |
Additional Credits
Journal
Transplant infectious disease
Publisher
Wiley
ISSN
1398-2273
Access(Rights)
restricted