Comparative features and outcomes of major neurological complications of COVID-19.
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BORIS DOI
Publisher DOI
PubMed ID
36314485
Description
BACKGROUND AND PURPOSE
The aim of this study was to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations.
METHODS
The data source was a registry established by the European Academy of Neurology during the first wave of the COVID-19 pandemic. Neurologists collected data on patients with COVID-19 seen as in- and outpatients and in emergency rooms in 23 European and seven non-European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID-19 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute/subacute selected neurological manifestations in patients with COVID-19 were analysed, comparing individuals with and without each condition for several risk factors.
RESULTS
By July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex/unknown, aged 16-101 years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute/subacute neurological manifestations were cognitive dysfunction (N = 449, 29.5%), stroke (N = 392, 25.7%), sleep-wake disturbances (N = 250, 16.4%), dysautonomia (N = 224, 14.7%), peripheral neuropathy (N = 145, 9.5%), movement disorders (N = 142, 9.3%), ataxia (N = 134, 8.8%), and seizures (N = 126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non-neurological manifestations, extent of association with other acute/subacute neurological manifestations, and outcome.
CONCLUSIONS
Patients with COVID-19 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID-19.
The aim of this study was to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations.
METHODS
The data source was a registry established by the European Academy of Neurology during the first wave of the COVID-19 pandemic. Neurologists collected data on patients with COVID-19 seen as in- and outpatients and in emergency rooms in 23 European and seven non-European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID-19 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute/subacute selected neurological manifestations in patients with COVID-19 were analysed, comparing individuals with and without each condition for several risk factors.
RESULTS
By July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex/unknown, aged 16-101 years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute/subacute neurological manifestations were cognitive dysfunction (N = 449, 29.5%), stroke (N = 392, 25.7%), sleep-wake disturbances (N = 250, 16.4%), dysautonomia (N = 224, 14.7%), peripheral neuropathy (N = 145, 9.5%), movement disorders (N = 142, 9.3%), ataxia (N = 134, 8.8%), and seizures (N = 126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non-neurological manifestations, extent of association with other acute/subacute neurological manifestations, and outcome.
CONCLUSIONS
Patients with COVID-19 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID-19.
Date of Publication
2023-02
Publication Type
Article
Subject(s)
Keyword(s)
COVID-19 coronavirus neurological complications neurology
Language(s)
en
Contributor(s)
Beghi, Ettore | |
Moro, Elena | |
Davidescu, Eugenia Irene | |
Popescu, Bogdan Ovidiu | |
Grosu, Oxana | |
Valzania, Franco | |
Cotelli, Maria Sofia | |
Kiteva-Trenchevska, Gordana | |
Zakharova, Maria | |
Kovács, Tibor | |
Armon, Carmel | |
Brola, Waldemar | |
Yasuda, Clarissa Lin | |
Maia, Luís F | |
Lovrencic-Huzjan, Arijana | |
de Seabra, Mafalda Maria Laracho | |
Avalos-Pavon, Rafael | |
Aamodt, Anne Hege | |
Meoni, Sara | |
Gryb, Victoria | |
Ozturk, Serefnur | |
Karadas, Omer | |
Krehan, Ingomar | |
Leone, Maurizio A | |
Lolich, Maria | |
Bianchi, Elisa | |
Rass, Verena | |
Helbok, Raimund |
Additional Credits
Series
European journal of neurology
Publisher
Wiley
ISSN
1468-1331
Access(Rights)
restricted