Post Tick-Borne Encephalitis Virus Vaccination Narcolepsy with Cataplexy.
Publisher DOI
PubMed ID
27397572
Abstract
STUDY OBJECTIVES
Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at identifying other vaccines associated with the onset of narcolepsy.
METHODS
Case series and retrospective database study.
RESULTS
We identified four cases of NC following a tick-borne encephalitis (TBE) vaccination with FSME Immun. Additional four cases could be detected in the database of the Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines in Germany.
CONCLUSIONS
Our findings implicate TBE vaccination as a potential additional environmental factor for the development of NC and add additional evidence for an immunological mechanism in the pathogenesis of the disease.
Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at identifying other vaccines associated with the onset of narcolepsy.
METHODS
Case series and retrospective database study.
RESULTS
We identified four cases of NC following a tick-borne encephalitis (TBE) vaccination with FSME Immun. Additional four cases could be detected in the database of the Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines in Germany.
CONCLUSIONS
Our findings implicate TBE vaccination as a potential additional environmental factor for the development of NC and add additional evidence for an immunological mechanism in the pathogenesis of the disease.
Date Issued
2016-10-01
Publication Type
Article
Subject(s)
Subjects
cataplexy
•
dendritic cells
•
granzyme
•
hypocretin
•
narcolepsy
•
tick-borne encephalitis virus vaccination
Language(s)
en
Journal
Sleep
Publisher
American Academy of Sleep Medicine
ISSN
0161-8105
Access(Rights)
metadata.only