Sex differences in urological management during spinal cord injury rehabilitation: results from a prospective multicenter longitudinal cohort study.
Publisher DOI
PubMed ID
36224336
Abstract
STUDY DESIGN
Prospective, multicenter, longitudinal cohort study.
OBJECTIVES
To describe female-male differences in first-line urological management during spinal cord injury (SCI) rehabilitation.
SETTING
Inpatient specialized post-acute SCI rehabilitation in Switzerland.
METHODS
Data on bladder storage medication (antimuscarinic and beta-3 agonist) use, suprapubic catheter placement, demographic and SCI characteristics was collected within 40 days of SCI and at rehabilitation discharge from May 2013-September 2021. Prevalence and indicators of bladder storage medication and suprapubic catheter use at discharge were investigated with sex-stratified descriptive and logistic regression analyses.
RESULTS
In 748 patients (219 females, 29%), bladder storage medication use at discharge had a prevalence of 24% (95% CI: 18-29%) for females and 30% (95% CI: 26-34%) for males and was indicated by cervical AIS grade A, B, C and traumatic SCI in both sexes. Thoracic AIS grade A, B, C SCI (males), and lumbar/sacral AIS grade A, B, C SCI (females) predicted higher odds of bladder storage medication use (SCI characteristic*sex interaction, p < 0.01). Prevalence of suprapubic catheter use at discharge was 22% (95% CI: 17-28%) for females and 17% (95% CI: 14-20%) for males. Suprapubic catheter use was indicated by cervical AIS grade A, B, C SCI, and age >60 in both sexes. Females with thoracic grade A, B, C SCI tended to have higher odds of suprapubic catheter use (SCI characteristic*sex interaction, p = 0.013).
CONCLUSIONS
We identified sex differences in urological management especially in persons with AIS grade C or higher sub-cervical SCI. There is scope for well-powered, female-specific research in SCI in order to understand the underlying mechanisms and support patient-tailored management.
Prospective, multicenter, longitudinal cohort study.
OBJECTIVES
To describe female-male differences in first-line urological management during spinal cord injury (SCI) rehabilitation.
SETTING
Inpatient specialized post-acute SCI rehabilitation in Switzerland.
METHODS
Data on bladder storage medication (antimuscarinic and beta-3 agonist) use, suprapubic catheter placement, demographic and SCI characteristics was collected within 40 days of SCI and at rehabilitation discharge from May 2013-September 2021. Prevalence and indicators of bladder storage medication and suprapubic catheter use at discharge were investigated with sex-stratified descriptive and logistic regression analyses.
RESULTS
In 748 patients (219 females, 29%), bladder storage medication use at discharge had a prevalence of 24% (95% CI: 18-29%) for females and 30% (95% CI: 26-34%) for males and was indicated by cervical AIS grade A, B, C and traumatic SCI in both sexes. Thoracic AIS grade A, B, C SCI (males), and lumbar/sacral AIS grade A, B, C SCI (females) predicted higher odds of bladder storage medication use (SCI characteristic*sex interaction, p < 0.01). Prevalence of suprapubic catheter use at discharge was 22% (95% CI: 17-28%) for females and 17% (95% CI: 14-20%) for males. Suprapubic catheter use was indicated by cervical AIS grade A, B, C SCI, and age >60 in both sexes. Females with thoracic grade A, B, C SCI tended to have higher odds of suprapubic catheter use (SCI characteristic*sex interaction, p = 0.013).
CONCLUSIONS
We identified sex differences in urological management especially in persons with AIS grade C or higher sub-cervical SCI. There is scope for well-powered, female-specific research in SCI in order to understand the underlying mechanisms and support patient-tailored management.
Date Issued
2023-01
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Anderson, Collene E | |
Birkhäuser, Veronika | |
Liechti, Martina D | |
Jordan, Xavier | |
Luca, Eugenia | |
Möhr, Sandra | |
Kessler, Thomas M | |
Brinkhof, Martin W G |
Additional Credits
Journal
Spinal cord
Publisher
Springer Nature
ISSN
1476-5624
Access(Rights)
restricted