Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro
Publisher DOI
PubMed ID
21511354
Abstract
Small cell lung cancer (SCLC) is one of the most aggressive malignancies implying a very poor prognosis for patients even under therapy. Since it is known that SCLC cells exhibit neurone-like characteristics, we investigated whether a neuronal induction medium (NID) consisting of indomethacin (200 ?M), 3-isobutyl-1-methylxanthine (IBMX, 500 ?M) and insulin (5 ?g/ml) induces neuronal differentiation and by this reduces malignancy of SCLC in vitro.
Date Issued
2011
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Lange, Annika | |
Gustke, Heike | |
Glassmeier, Günter | |
Heine, Markus | |
Schwarz, Jürgen R | |
Schumacher, Udo | |
Lange, Tobias |
Additional Credits
Journal
Lung cancer
Publisher
Elsevier
ISSN
0169-5002
Access(Rights)
metadata.only