Granulocyte death mediated by specific antibodies in intravenous immunoglobulin (IVIG).

BORIS DOI
Publisher DOI
PubMed ID
30738127
Description
Granulocytes are key effector cells of the innate immune system that cause substantial by-stander tissue damage in a broad range of inflammatory disorders. Specific antibodies with the potential to regulate granulocyte survival are present in polyclonal intravenous immunoglobulin (IVIG) preparations and may contribute to the anti-inflammatory effects of high-dose IVIG therapy. Here, we discuss idiosyncratic characteristics of antibodies to FAS and Siglecs contained in IVIG pertaining to granulocyte death regulation and highlight implications for research and clinical practice.
Date of Publication
2020-04
Publication Type
Article
Subject(s)
Keyword(s)
Eosinophils FAS Granulocytes High-dose IVIG IVIG Immunomodulation Intravenous immunoglobulin Neutrophils Siglec-8 Siglec-9
Language(s)
en
Contributor(s)
Additional Credits
Series
Pharmacological research
Publisher
Elsevier
ISSN
1043-6618
Access(Rights)
restricted
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