A Rare Case of a Plasmacytoid and Sarcomatoid Differentiated Urothelial Bladder Carcinoma with a Single Metastasis to the Right Ventricle of the Heart and Rapid Review of Single Heart Metastasis in Bladder Cancer.
Publisher DOI
PubMed ID
40288361
Abstract
Introduction
Distant metastases and especially single side metastases of non-muscle invasive bladder cancer (NMIBC) without regional progression in lymph nodes are extremely uncommon and rare.Case Presentation
We report a case of a plasmacytoid and sarcomatoid differentiated urothelial NMIIC with a single metastasis to the right ventricle of the heart, which was surgically resected, but the patient died shortly after the resection with progressive metastatic disease. To the best of our knowledge, this is the first case with two different variant histologies in NMIBC with a single heart metastasis. Furthermore, we conducted a rapid review using MEDLINE regarding single heart metastasis of bladder cancer. Four cases have been identified. Interestingly, with 2 cases of variant histology and one with single plasmacytoid differentiation, also being NMIBC.Conclusion
These findings underline the aggressiveness of the variant histologies in NMIBC, especially plasmacytoid differentiation, and may favor an early and aggressive treatment regimen. Further scientific research concerning the optimal treatment of histologically variant bladder cancer is absolutely needed.
Distant metastases and especially single side metastases of non-muscle invasive bladder cancer (NMIBC) without regional progression in lymph nodes are extremely uncommon and rare.Case Presentation
We report a case of a plasmacytoid and sarcomatoid differentiated urothelial NMIIC with a single metastasis to the right ventricle of the heart, which was surgically resected, but the patient died shortly after the resection with progressive metastatic disease. To the best of our knowledge, this is the first case with two different variant histologies in NMIBC with a single heart metastasis. Furthermore, we conducted a rapid review using MEDLINE regarding single heart metastasis of bladder cancer. Four cases have been identified. Interestingly, with 2 cases of variant histology and one with single plasmacytoid differentiation, also being NMIBC.Conclusion
These findings underline the aggressiveness of the variant histologies in NMIBC, especially plasmacytoid differentiation, and may favor an early and aggressive treatment regimen. Further scientific research concerning the optimal treatment of histologically variant bladder cancer is absolutely needed.
Date Issued
2026
Publication Type
Article
Subjects
Bladder cancer
•
Heart metastasis
•
Non-muscle invasive bladder cancer
•
Urothelial cancer
•
Variant histology
Language(s)
en
Additional Credits
Journal
Urologia Internationalis
Publisher
Karger Publishers
ISSN
1423-0399
0042-1138
Access(Rights)
metadata.only