Publication:
Impact of Aging on Liver Cells and Liver Disease: Focus on the Biliary and Vascular Compartments.

cris.virtual.author-orcid0000-0002-5664-6746
cris.virtualsource.author-orciddf14a5aa-12a0-466d-afd0-3d8735602577
cris.virtualsource.author-orcid7e864d52-0288-4a65-9911-dcc152e46e55
datacite.rightsopen.access
dc.contributor.authorBaiocchi, Leonardo
dc.contributor.authorGlaser, Shannon
dc.contributor.authorFrancis, Heather
dc.contributor.authorKennedy, Lindsey
dc.contributor.authorFelli, Eric
dc.contributor.authorAlpini, Gianfranco
dc.contributor.authorGracia Sancho, Jorge Sergio
dc.date.accessioned2024-10-05T06:52:37Z
dc.date.available2024-10-05T06:52:37Z
dc.date.issued2021-07
dc.description.abstractThe aging process is represented by the time-dependent decay in physiologic functions of living beings. Major interest has been focused in recent years on the determinants of this progressive condition due to its correlative relationship with the onset of diseases. Several hallmark features have been observed in aging, such as genetic alterations, mitochondrial impairment, and telomere shortening. At the cellular level, a senescent phenotype has been identified in response to aging that is characterized by a flat appearance, proliferative arrest, and production of specific molecules. The net effect of these cells in the course of diseases is an argument of debate. In fact, while the onset of a senescent phenotype may prevent tumor spreading, these cells appear to support pathological processes in some conditions. Several studies are now focused on clarifying the specific molecular pathways of aging/senescence in different cells, tissues, or organs. Biliary and vascular components, within the liver, have emerged as important determinants of some form of liver disease. In this review we summarize the most recent achievements on aging/senescence, focusing on the biliary and vascular liver system. Conclusion: Several findings, in both preclinical animal models and on human liver specimens, converge in supporting the presence of specific aging hallmarks in the diseases involving these hepatic compartments.
dc.description.numberOfPages13
dc.description.sponsorshipDepartment for BioMedical Research, Hepatologie Forschung
dc.identifier.doi10.48350/160345
dc.identifier.pmid34278165
dc.identifier.publisherDOI10.1002/hep4.1725
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/53848
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofHepatology communications
dc.relation.issn2471-254X
dc.relation.organizationDCD5A442C6DFE17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleImpact of Aging on Liver Cells and Liver Disease: Focus on the Biliary and Vascular Compartments.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage1137
oaire.citation.issue7
oaire.citation.startPage1125
oaire.citation.volume5
oairecerif.author.affiliationDepartment for BioMedical Research, Hepatologie Forschung
oairecerif.author.affiliationDepartment for BioMedical Research, Hepatologie Forschung
unibe.contributor.rolecreator
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unibe.contributor.rolecreator
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unibe.date.licenseChanged2021-10-27 05:46:08
unibe.description.ispublishedpub
unibe.eprints.legacyId160345
unibe.refereedtrue
unibe.subtype.articlereview

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