Synthesis and biological evaluation of epothilone A dimeric compounds
Publisher DOI
PubMed ID
19804980
Abstract
The preparation and biological evaluation of a novel series of dimeric epothilone A derivatives (1-6) are described. Two types of diacyl spacers were introduced to establish the various dimeric epothilone A constructs. The effect of these compounds on tubulin polymerization and their cytotoxicity against four different cancer cell lines are reported. Several of the newly synthesized compounds inhibit endothelial cell differentiation and endothelial cell migration that are key steps of the angiogenic process.
Date Issued
2009
Publication Type
Article
Language(s)
en
Author(s)
Passarella, Daniele | |
Comi, Daniela | |
Cappelletti, Graziella | |
Cartelli, Daniele | |
Quesada, Ana R | |
Borlak, Jurgen | |
Altmann, Karl-Heinz |
Additional Credits
Journal
Bioorganic & medicinal chemistry
Publisher
Elsevier
ISSN
0968-0896
Access(Rights)
metadata.only