Molecular epidemiology of tuberculosis in Cambodian children
Publisher DOI
PubMed ID
25050615
Abstract
SUMMARY We analysed Mycobacterium tuberculosis strains from children, hospitalized from January 2004 to July 2008 in the largest paediatric hospital complex in Cambodia. Specimens were tested for drug susceptibility and genotypes. From the 260 children, 161 strains were available. The East African-Indian genotype family was the most common (59·0%), increasing in frequency with distance from the Phnom Penh area, while the frequency of the Beijing genotype family strains decreased. The drug resistance pattern showed a similar geographical gradient: lowest in the northwest (4·6%), intermediate in the central (17·1%), and highest in the southeastern (30·8%) parts of the country. Three children (1·9%) had multidrug-resistant tuberculosis. The Beijing genotype and streptomycin resistance were significantly associated (P < 0·001). As tuberculosis in children reflects recent transmission patterns in the community, multidrug resistance levels inform about the current quality of the tuberculosis programme.
Date Issued
2015
Publication Type
Article
Language(s)
en
Author(s)
Rieder, H L | |
van Soolingen, D | |
Chantana, Y | |
Studer, P | |
Laurent, D | |
Richner, B |
Journal
Epidemiology and infection
Publisher
Cambridge University Press
ISSN
0950-2688
Access(Rights)
open.access