Evaluating long-term outcomes of three approaches to retroperitoneal staging in endometrial cancer.
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BORIS DOI
Publisher DOI
PubMed ID
35725656
Description
OBJECTIVE
Sentinel lymph node mapping (SNM) has gained popularity in managing apparent early-stage endometrial cancer (EC). Here, we evaluated the long-term survival of three different approaches of nodal assessment.
METHODS
This is a multi-institutional retrospective study evaluating long-term outcomes of EC patients having nodal assessment between 01/01/2006 and 12/31/2016. In order to reduce possible confounding factors, we applied a propensity-matched algorithm.
RESULTS
Overall, 940 patients meeting inclusion criteria were included in the study, of which 174 (18.5%), 187 (19.9%), and 579 (61.6%) underwent SNM, SNM followed by backup lymphadenectomy (LND) and LND alone, respectively. Applying a propensity score matching algorithm (1:1:2) we selected 500 patients, including 125 SNM, 125 SNM/backup LND, and 250 LND. Baseline characteristics of the study population were similar between groups. The prevalence of nodal disease was 14%, 16%, and 12% in patients having SNM, SNM/backup LND and LND, respectively. Overall, 19 (7.6%) patients were diagnosed with low volume nodal disease. The survival analysis comparing the three techniques did not show statistical differences in terms of disease-free (p = 0.750) and overall survival (p = 0.899). Similarly, the type of nodal assessment did not impact survival outcomes after stratification based on uterine risk factors.
CONCLUSION
Our study highlighted that SNM provides similar long-term oncologic outcomes than LND.
Sentinel lymph node mapping (SNM) has gained popularity in managing apparent early-stage endometrial cancer (EC). Here, we evaluated the long-term survival of three different approaches of nodal assessment.
METHODS
This is a multi-institutional retrospective study evaluating long-term outcomes of EC patients having nodal assessment between 01/01/2006 and 12/31/2016. In order to reduce possible confounding factors, we applied a propensity-matched algorithm.
RESULTS
Overall, 940 patients meeting inclusion criteria were included in the study, of which 174 (18.5%), 187 (19.9%), and 579 (61.6%) underwent SNM, SNM followed by backup lymphadenectomy (LND) and LND alone, respectively. Applying a propensity score matching algorithm (1:1:2) we selected 500 patients, including 125 SNM, 125 SNM/backup LND, and 250 LND. Baseline characteristics of the study population were similar between groups. The prevalence of nodal disease was 14%, 16%, and 12% in patients having SNM, SNM/backup LND and LND, respectively. Overall, 19 (7.6%) patients were diagnosed with low volume nodal disease. The survival analysis comparing the three techniques did not show statistical differences in terms of disease-free (p = 0.750) and overall survival (p = 0.899). Similarly, the type of nodal assessment did not impact survival outcomes after stratification based on uterine risk factors.
CONCLUSION
Our study highlighted that SNM provides similar long-term oncologic outcomes than LND.
Date of Publication
2022-08
Publication Type
Article
Subject(s)
Keyword(s)
Endometrial cancer Laparoscopy Lymphadenectomy Sentinel node mapping Staging surgery
Language(s)
en
Contributor(s)
Bogani, Giorgio | |
Di Donato, Violante | |
Papadia, Andrea | |
Buda, Alessandro | |
Casarin, Jvan | |
Multinu, Francesco | |
Plotti, Francesco | |
Cuccu, Ilaria | |
D'Auge, Tullio Golia | |
Gasparri, Maria Luisa | |
Pinelli, Ciro | |
Perrone, Anna Myriam | |
Barra, Fabio | |
Sorbi, Flavia | |
Cromi, Antonella | |
Di Martino, Giampaolo | |
Palaia, Innocenza | |
Perniola, Giorgia | |
Ferrero, Simone | |
De Iaco, Pierandrea | |
Perrone, Chiara | |
Angioli, Roberto | |
Luvero, Daniela | |
Muzii, Ludovico | |
Ghezzi, Fabio | |
Landoni, Fabio | |
Benedetti Panici, Pierluigi | |
Raspagliesi, Francesco |
Additional Credits
Series
Gynecologic oncology
Publisher
Elsevier
ISSN
1095-6859
Access(Rights)
restricted