Impact of corneal cross-linking on topical drug penetration in humans.
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BORIS DOI
Publisher DOI
PubMed ID
25402571
Description
PURPOSE
To analyse the influence of corneal cross-linking (CXL) with ultraviolet-A (UV-A) and riboflavin on drug permeability in human subjects.
METHODS
Keratoconus patients (n = 23; mean age 26.9 ± 5.8 years) undergoing a standard CXL procedure with UV-A (5.4 J/cm(2) , 30 min) and riboflavin in one eye were included in the study. The pupillary diameter, measured before and every 3 min for 30 min after the topical application of one drop of 2% pilocarpine, was used as an indirect measure of the corneal permeability. The pupillary diameter was measured with an infrared pupillometer device before (baseline) and 4 months after CXL.
RESULTS
Prior to pilocarpine application, no significant difference in the pupillary diameter was detected before CXL and 4 months later. The mean decrease in the pupillary diameter after the application of pilocarpine was similar at baseline and the 4-month follow-up visit: mean decreases of 3.9 and 3.7 mm were observed 30 min after pilocarpine application, respectively (p > 0.05).
CONCLUSIONS
No significant influence of CXL on the corneal penetration of topically applied pilocarpine was observed in this clinical study.
To analyse the influence of corneal cross-linking (CXL) with ultraviolet-A (UV-A) and riboflavin on drug permeability in human subjects.
METHODS
Keratoconus patients (n = 23; mean age 26.9 ± 5.8 years) undergoing a standard CXL procedure with UV-A (5.4 J/cm(2) , 30 min) and riboflavin in one eye were included in the study. The pupillary diameter, measured before and every 3 min for 30 min after the topical application of one drop of 2% pilocarpine, was used as an indirect measure of the corneal permeability. The pupillary diameter was measured with an infrared pupillometer device before (baseline) and 4 months after CXL.
RESULTS
Prior to pilocarpine application, no significant difference in the pupillary diameter was detected before CXL and 4 months later. The mean decrease in the pupillary diameter after the application of pilocarpine was similar at baseline and the 4-month follow-up visit: mean decreases of 3.9 and 3.7 mm were observed 30 min after pilocarpine application, respectively (p > 0.05).
CONCLUSIONS
No significant influence of CXL on the corneal penetration of topically applied pilocarpine was observed in this clinical study.
Date of Publication
2014-11-17
Publication Type
Article
Subject(s)
Keyword(s)
in vivo
•
cornea
•
corneal cross-linking
•
drug penetration
•
keratoconus
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pilocarpine
•
pupillometry
Language(s)
en
Additional Credits
Series
Acta ophthalmologica
Publisher
Blackwell Munksgaard
ISSN
1755-375X
Access(Rights)
restricted