Determinants of VO2peak changes after aerobic training in coronary heart disease patients.
Publisher DOI
PubMed ID
38267005
Abstract
This study aimed to highlight the ventilatory and circulatory determinants of changes in VO2peak after exercise-based cardiac rehabilitation (ECR) in patients with coronary heart disease (CHD). Eighty-two CHD patients performed, before and after a 3-month ECR, a cardiopulmonary exercise testing (CPET) on a bike with gas exchanges measurments (VO2peak, minute ventilation; VE) and cardiac output (Qc). The arteriovenous difference in O2 (C(a-v )O2) and the alveolar capillary gradient in O2 (PAi-aO2) were calculated using Fick's laws. Oxygen uptake efficiency slope (OUES) was calculated. A 5.0% cut off was applied for differentiating non- (NR: ∆VO2<0.0%), low (LR: 0.0≤ ∆VO2<5.0%), moderate- (MR: 5.0≤∆VO2<10.0%) and high responders (HR: ∆VO2≥10.0%) to ECR. Forty-four % of patients were HR (n=36), 20% MR (n=16), 23% LR (n=19) and 13% NR (n=11). For HR, the VO2peak increase (p<0.01) was associated to increases in VE (+12.8±13.0L/min, p<0.01), Qc (+1.0±0.9L/min, p<0.01), and C(a-v)O2 (+2.3±2.5mLO2/100mL, p<0.01). MR patients were characterized by +6.7±19.7L/min increase in VE (p=0.04) and +0.7±1.0L/min of Qc (p<0.01). ECR induced decreases in VE (p=0.04) and C(a-v )O2 (p<0.01) and Qc increase in LR and NR patients (p<0.01). Peripheral and ventilatory responses more than central adaptations could responsible of the VO2peak change with ECR in CHD patients.
Date Issued
2024-06
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Guirault, Axel | |
Leprêtre, Pierre-Marie | |
Besnier, Florent | |
Boidin, Maxime | |
Lalongé, Julie | |
Juneau, Martin | |
Bherer, Louis | |
Nigam, Anil | |
Gayda, Mathieu |
Additional Credits
Journal
International journal of sports medicine
Publisher
Thieme
ISSN
1439-3964
Access(Rights)
metadata.only