Demography, Clinical Characteristics and Long-Term Outcomes of Central Serous Chorioretinopathy in Women. MICRoN report number Fourteen.
Publisher DOI
PubMed ID
41765268
Abstract
Purpose
To evaluate the characteristics and longitudinal outcomes of chronic central serous chorioretinopathy (CSCR) in women compared to an age-matched cohort of men with CSCR.Design
Retrospective, multicenter clinical cohort study from the Macula Society CSCR Study Group.Participants
This study included 426 eyes (213 women and 213 age-matched men) with a diagnosis of CSCR.Methods
Baseline and final best-recorded visual acuity (BRVA) and multimodal imaging parameters such as area of retinal pigment epithelium (RPE) alterations, choroidal macular thickness (CMT), sub-foveal choroidal thickness (SFCT), subretinal fluid (SRF), pigment epithelium detachment (PED), double layer sign (DLS), hyperreflective dots (HRD), as well as the presence of choroidal neovascularization (CNV) and subretinal hyperreflective material (SHRM) were assessed. Regression analysis was used to evaluate baseline predictors of final visual acuity.Main Outcome Measures
Longitudinal changes in BRVA and imaging parameters in men and women stratified for age; factors affecting subretinal fluid (SRF) persistence, and change in BRVA.Results
A total of 426 eyes (213 women and 213 age-matched men) with CSCR were analyzed. Women showed better BRVA at presentation (0.25 ± 0.24 vs 0.31 ± 0.35 logMAR; p = 0.05), and exhibited smaller areas of RPE alterations (2.37 ± 2.64 vs 1.59 ± 1.55 disc areas; p = 0.003), less frequent peripapillary RPE changes (13.6% vs 7.5%; p < 0.001), shorter DLS (1353.9 ± 970.2 vs 1071.6 ± 888.7 µm; p = 0.039), and smaller PEDs (644.9 ± 546.4 vs 442.1 ± 278.9 µm; p = 0.022). During follow-up, women exhibited higher rates of complete SRF resolution (p=0.001) while persistence and the number of recurrences were significantly more common in men (p=0.006 and p=0.02, respectively). Logistic regression analysis revealed that persistent SRF was independently associated with complex CSCR, male gender, baseline PROS irregularities, worse BRVA, SHRM, and CNV, while PDT was protective.Conclusion
Women had better visual outcomes and more favorable structural evolution while men tended to present with more complex anatomical alterations and experience higher rates of persistent SRF.
To evaluate the characteristics and longitudinal outcomes of chronic central serous chorioretinopathy (CSCR) in women compared to an age-matched cohort of men with CSCR.Design
Retrospective, multicenter clinical cohort study from the Macula Society CSCR Study Group.Participants
This study included 426 eyes (213 women and 213 age-matched men) with a diagnosis of CSCR.Methods
Baseline and final best-recorded visual acuity (BRVA) and multimodal imaging parameters such as area of retinal pigment epithelium (RPE) alterations, choroidal macular thickness (CMT), sub-foveal choroidal thickness (SFCT), subretinal fluid (SRF), pigment epithelium detachment (PED), double layer sign (DLS), hyperreflective dots (HRD), as well as the presence of choroidal neovascularization (CNV) and subretinal hyperreflective material (SHRM) were assessed. Regression analysis was used to evaluate baseline predictors of final visual acuity.Main Outcome Measures
Longitudinal changes in BRVA and imaging parameters in men and women stratified for age; factors affecting subretinal fluid (SRF) persistence, and change in BRVA.Results
A total of 426 eyes (213 women and 213 age-matched men) with CSCR were analyzed. Women showed better BRVA at presentation (0.25 ± 0.24 vs 0.31 ± 0.35 logMAR; p = 0.05), and exhibited smaller areas of RPE alterations (2.37 ± 2.64 vs 1.59 ± 1.55 disc areas; p = 0.003), less frequent peripapillary RPE changes (13.6% vs 7.5%; p < 0.001), shorter DLS (1353.9 ± 970.2 vs 1071.6 ± 888.7 µm; p = 0.039), and smaller PEDs (644.9 ± 546.4 vs 442.1 ± 278.9 µm; p = 0.022). During follow-up, women exhibited higher rates of complete SRF resolution (p=0.001) while persistence and the number of recurrences were significantly more common in men (p=0.006 and p=0.02, respectively). Logistic regression analysis revealed that persistent SRF was independently associated with complex CSCR, male gender, baseline PROS irregularities, worse BRVA, SHRM, and CNV, while PDT was protective.Conclusion
Women had better visual outcomes and more favorable structural evolution while men tended to present with more complex anatomical alterations and experience higher rates of persistent SRF.
Date Issued
2026-06
Publication Type
Article
Subjects
CSCR
•
central serous chorioretinopathy
•
follow-up
•
women
Language(s)
en
Author(s)
Gregori, Giulia | |
Sahoo, Niroj Kumar | |
Hasan, Nasiq | |
Zarnegar, Arman | |
Lupidi, Marco | |
Zhang, Micheal | |
Wu, Lihteh | |
Cao, Jessica | |
Piccoli, Gabriele | |
Vujosevic, Stela | |
Shah, Priya | |
Singhanetr, Panisa | |
Rossin, Elizabeth | |
Checchin, Lisa | |
Pili, Lorenzo | |
Parodi, Maurizio Battaglia | |
Kim, Min | |
Desideri, Lorenzo Ferro | |
Chotcomwongse, Peranut | |
Ruamviboonsuk, Paisan | |
Fung, Adrian | |
Small, Kent | |
Khateb, Samer | |
Wang, Jay C | |
Khurana, Rahul N | |
Villafeurte, Carol | |
Yiu, Glenn | |
Momenaei, Bita | |
Garg, Sunir | |
Lai, Timothy | |
Ashfaq, Yusuf | |
Kroeger, Zachary | |
Chhablani, Jay |
Additional Credits
Journal
American Journal of Ophthalmology
Publisher
Elsevier
ISSN
1879-1891
0002-9394
Access(Rights)
open.access