Multidrug strategies are effective in the treatment of severe experimental pancreatitis
Publisher DOI
PubMed ID
21982067
Abstract
Trypsinogen activation, oxygen radicals, cytokines, leukocyte infiltration, and pancreatic ischemia are important steps in the pathogenesis of necrotizing pancreatitis and associated systemic complications. Several drugs that inhibit those pathogenetic steps attenuated biochemical and histologic changes, while survival remained low. The aim of the present study was to evaluate the benefit of multidrug approaches compared to monotherapies on organ injury and survival in acute experimental pancreatitis in the rat model of retrograde bile injection combined with intravenous cerulein.
Date Issued
2012
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Werner, Jens | |
Hartwig, Werner | |
Hackert, Thilo | |
Schmidt, Jan | |
Gebhard, Martha M | |
Büchler, Markus W | |
Klar, Ernst |
Additional Credits
Journal
Surgery
Publisher
Elsevier
ISSN
0039-6060
Access(Rights)
metadata.only