A Case Report with Hutchinson's Sign: What Could It Be Other than Melanoma in situ?
Publisher DOI
PubMed ID
41938991
Abstract
Introduction
Many conditions, such as malnutrition, radiation exposure, drugs, trauma, and systemic and metabolic disorders, can lead to nail pigmentation. Many other dermatological and systemic conditions, mycologic and bacterial infections, and repetitive trauma can be associated with non-melanoma-related Hutchinson's sign.Case Presentation
We report a 68-year-old woman with the complaint of darkening of her existing nail bands and development of a newly pigmented lesion on the edge of her left thumb after taking chemotherapy. Lateral longitudinal biopsy, including Hutchinson's sign, was performed. Melanocytes in normal number and localization in the nail matrix on histopathological evaluation. The patient was diagnosed with frictional hypermelanosis.Conclusion
It is very important to exclude subungual melanoma and to find out the etiology of Hutchinson's sign. Repetitive trauma can be a cause of non-melanoma Hutchinson's sign.
Many conditions, such as malnutrition, radiation exposure, drugs, trauma, and systemic and metabolic disorders, can lead to nail pigmentation. Many other dermatological and systemic conditions, mycologic and bacterial infections, and repetitive trauma can be associated with non-melanoma-related Hutchinson's sign.Case Presentation
We report a 68-year-old woman with the complaint of darkening of her existing nail bands and development of a newly pigmented lesion on the edge of her left thumb after taking chemotherapy. Lateral longitudinal biopsy, including Hutchinson's sign, was performed. Melanocytes in normal number and localization in the nail matrix on histopathological evaluation. The patient was diagnosed with frictional hypermelanosis.Conclusion
It is very important to exclude subungual melanoma and to find out the etiology of Hutchinson's sign. Repetitive trauma can be a cause of non-melanoma Hutchinson's sign.
Date Issued
2026-04
Publication Type
Article
Subject(s)
Subjects
Hypermelanosis
•
Hyperpigmentation
•
Nail disorders
•
Side effects of drugs
Language(s)
en
Author(s)
Atış, Güldehan | |
Doğruel, Gaye Güldiken | |
Güneş, Pembegül |
Additional Credits
Journal
Skin Appendage Disorders
Publisher
Karger Publishers
ISSN
2296-9195
Access(Rights)
metadata.only