The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors
Publisher DOI
PubMed ID
22646533
Abstract
Pharmacological activation of cannabinoid CB(1) and CB(2) receptors is a therapeutic strategy to treat chronic and inflammatory pain. It was recently reported that a mixture of natural triterpenes α- and β-amyrin bound selectively to CB(1) receptors with a subnanomolar K(i) value (133 pM). Orally administered α/β-amyrin inhibited inflammatory and persistent neuropathic pain in mice through both CB(1) and CB(2) receptors. Here, we investigated effects of amyrins on the major components of the endocannabinoid system.
Date Issued
2012
Publication Type
Article
Language(s)
en
Additional Credits
Journal
British journal of pharmacology
Publisher
Wiley-Blackwell
ISSN
0007-1188
Access(Rights)
metadata.only