Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

BORIS DOI
Publisher DOI
PubMed ID
23708141
Description
Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
Date of Publication
2013-07
Publication Type
Article
Subject(s)
Language(s)
en
Contributor(s)
Conductier, Grégory
Brau, Frédéric
Viola, Angèle
Langlet, Fanny
Ramkumar, Navean
Dehouck, Bénédicte
Lemaire, Thibault
Chapot, Raphaël
Lucas, Laurianne
Rovère, Carole
Maitre, Priscilla
Hosseiny, Salma
Petit-Paitel, Agnès
Lakaye, Bernard
Risold, Pierre-Yves
Prévot, Vincent
Meste, Olivier
Nahon, Jean-Louis
Guyon, Alice
Additional Credits
Series
Nature neuroscience
Publisher
Nature America
ISSN
1097-6256
Access(Rights)
restricted
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