Publication:
Theta burst stimulation reduces disability during the activities of daily living in spatial neglect

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cris.virtualsource.author-orcid266acf6f-fe2b-416b-88e0-e2f3eabb04c2
dc.contributor.authorCazzoli, Dario
dc.contributor.authorMüri, René Martin
dc.contributor.authorSchumacher, Rahel
dc.contributor.authorvon Arx, Sebastian
dc.contributor.authorChaves, Silvia
dc.contributor.authorGutbrod, Klemens
dc.contributor.authorBohlhalter, Stephan
dc.contributor.authorBauer, Daniel
dc.contributor.authorVanbellingen, Tim
dc.contributor.authorBertschi, Manuel
dc.contributor.authorKipfer, Stefan
dc.contributor.authorRosenthal, Clive R
dc.contributor.authorKennard, Christopher
dc.contributor.authorBassetti, Claudio L.A.
dc.contributor.authorNyffeler, Thomas
dc.date.accessioned2024-10-11T09:43:59Z
dc.date.available2024-10-11T09:43:59Z
dc.date.issued2012
dc.description.abstractLeft-sided spatial neglect is a common neurological syndrome following right-hemispheric stroke. The presence of spatial neglect is a powerful predictor of poor rehabilitation outcome. In one influential account of spatial neglect, interhemispheric inhibition is impaired and leads to a pathological hyperactivity in the contralesional hemisphere, resulting in a biased attentional allocation towards the right hemifield. Inhibitory transcranial magnetic stimulation can reduce the hyperactivity of the contralesional, intact hemisphere and thereby improve spatial neglect symptoms. However, it is not known whether this improvement is also relevant to the activities of daily living during spontaneous behaviour. The primary aim of the present study was to investigate whether the repeated application of continuous theta burst stimulation trains could ameliorate spatial neglect on a quantitative measure of the activities of daily living during spontaneous behaviour. We applied the Catherine Bergego Scale, a standardized observation questionnaire that can validly and reliably detect the presence and severity of spatial neglect during the activities of daily living. Eight trains of continuous theta burst stimulation were applied over two consecutive days on the contralesional, left posterior parietal cortex in patients suffering from subacute left spatial neglect, in a randomized, double-blind, sham-controlled design, which also included a control group of neglect patients without stimulation. The results showed a 37% improvement in the spontaneous everyday behaviour of the neglect patients after the repeated application of continuous theta burst stimulation. Remarkably, the improvement persisted for at least 3 weeks after stimulation. The amelioration of spatial neglect symptoms in the activities of daily living was also generally accompanied by significantly better performance in the neuropsychological tests. No significant amelioration in symptoms was observed after sham stimulation or in the control group without stimulation. These results provide Class I evidence that continuous theta burst stimulation is a viable add-on therapy in neglect rehabilitation that facilitates recovery of normal everyday behaviour.
dc.description.numberOfPages14
dc.description.sponsorshipUniversitätsklinik für Neurologie
dc.description.sponsorshipARTORG - Gerontechnology and Rehabilitation
dc.identifier.doi10.7892/boris.9435
dc.identifier.isi000311644800027
dc.identifier.pmid22831781
dc.identifier.publisherDOI10.1093/brain/aws182
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/79721
dc.language.isoen
dc.publisherOxford University Press
dc.publisher.placeOxford
dc.relation.ispartofBrain
dc.relation.issn0006-8950
dc.relation.organizationDCD5A442BAE0E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442C49BE17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleTheta burst stimulation reduces disability during the activities of daily living in spatial neglect
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage3439
oaire.citation.issuePt 11
oaire.citation.startPage3426
oaire.citation.volume135
oairecerif.author.affiliationARTORG - Gerontechnology and Rehabilitation
oairecerif.author.affiliationUniversitätsklinik für Neurologie
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oairecerif.author.affiliationUniversitätsklinik für Neurologie
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oairecerif.author.affiliationUniversitätsklinik für Neurologie
oairecerif.author.affiliationUniversitätsklinik für Neurologie
oairecerif.author.affiliationUniversitätsklinik für Neurologie
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unibe.date.licenseChanged2019-10-28 19:55:01
unibe.description.ispublishedpub
unibe.eprints.legacyId9435
unibe.journal.abbrevTitleBRAIN
unibe.refereedTRUE
unibe.subtype.articlejournal

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