Statins induce regulatory T cell recruitment via a CCL1 dependent pathway
PubMed ID
18714025
Abstract
The statins, a group of inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are reported to influence a variety of immune system activities through 3-hydroxy-3-methylglutaryl coenzyme A reductase-dependent and -independent mechanisms. How statin treatment regulates immune system function in vivo nonetheless remains to be fully defined. We analyzed the immunomodulatory effects of lovastatin in a Candida albicans-induced delayed-type hypersensitivity reaction in mice. In this model, lovastatin administration reduced the acute inflammatory response elicited by C. albicans challenge. This anti-inflammatory activity of lovastatin was associated with a shift from a Th1 to a Th2 immune response, as well as an increase in the percentage of regulatory T cells at the inflammation site and in the regional draining lymph node. The lovastatin-induced increase in regulatory T cells in the inflamed skin was dependent on expression of CCL1, a chemokine that is locally up-regulated by statin administration. The anti-inflammatory effect of lovastatin was abrogated in CCL1-deficient mice. These results suggest that local regulation of chemokine expression may be an important process in statin-induced modulation of the immune system.
Date Issued
2008
Publication Type
Article
Language(s)
en
Author(s)
Mira, Emilia | |
León, Beatriz | |
Barber, Domingo F | |
Jiménez-Baranda, Sonia | |
Goya, Iñigo | |
Almonacid, Luis | |
Márquez, Gabriel | |
Zaballos, Angel | |
Martínez-A, Carlos | |
Ardavín, Carlos | |
Mañes, Santos |
Additional Credits
Journal
Journal of immunology
Publisher
American Association of Immunologists
ISSN
0022-1767
ISBN
18714025
Access(Rights)
metadata.only