Fibrin Sealants and Axillary Lymphatic Morbidity: A Systematic Review and Meta-Analysis of 23 Clinical Randomized Trials.
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BORIS DOI
Publisher DOI
PubMed ID
33923153
Description
BACKGROUND
use of fibrin sealants following pelvic, paraaortic, and inguinal lymphadenectomy may reduce lymphatic morbidity. The aim of this meta-analysis is to evaluate if this finding applies to the axillary lymphadenectomy.
METHODS
randomized trials evaluating the efficacy of fibrin sealants in reducing axillary lymphatic complications were included. Lymphocele, drainage output, surgical-site complications, and hospital stay were considered as outcomes.
RESULTS
twenty-three randomized studies, including patients undergoing axillary lymphadenectomy for breast cancer, melanoma, and Hodgkin's disease, were included. Fibrin sealants did not affect axillary lymphocele incidence nor the surgical site complications. Drainage output, days with drainage, and hospital stay were reduced when fibrin sealants were applied (p < 0.0001, p < 0.005, p = 0.008).
CONCLUSION
fibrin sealants after axillary dissection reduce the total axillary drainage output, the duration of drainage, and the hospital stay. No effects on the incidence of postoperative lymphocele and surgical site complications rate are found.
use of fibrin sealants following pelvic, paraaortic, and inguinal lymphadenectomy may reduce lymphatic morbidity. The aim of this meta-analysis is to evaluate if this finding applies to the axillary lymphadenectomy.
METHODS
randomized trials evaluating the efficacy of fibrin sealants in reducing axillary lymphatic complications were included. Lymphocele, drainage output, surgical-site complications, and hospital stay were considered as outcomes.
RESULTS
twenty-three randomized studies, including patients undergoing axillary lymphadenectomy for breast cancer, melanoma, and Hodgkin's disease, were included. Fibrin sealants did not affect axillary lymphocele incidence nor the surgical site complications. Drainage output, days with drainage, and hospital stay were reduced when fibrin sealants were applied (p < 0.0001, p < 0.005, p = 0.008).
CONCLUSION
fibrin sealants after axillary dissection reduce the total axillary drainage output, the duration of drainage, and the hospital stay. No effects on the incidence of postoperative lymphocele and surgical site complications rate are found.
Date of Publication
2021-04-24
Publication Type
Article
Subject(s)
Keyword(s)
axillary lymphadenectomy breast cancer fibrin sealant lymphatic morbidity lymphocele
Language(s)
en
Contributor(s)
Gasparri, Maria Luisa | |
Kuehn, Thorsten | |
Ruscito, Ilary | |
Zuber, Veronica | |
Di Micco, Rosa | |
Galiano, Ilaria | |
Navarro Quinones, Siobana C | |
Santurro, Letizia | |
Di Vittorio, Francesca | |
Meani, Francesco | |
Bassi, Valerio | |
Ditsch, Nina | |
Bellati, Filippo | |
Caserta, Donatella | |
Papadia, Andrea | |
Gentilini, Oreste D |
Additional Credits
Series
Cancers
Publisher
MDPI AG
ISSN
2072-6694
Access(Rights)
open.access