Short-term effect of Ketogenic diet and Low-calorie diet on Ketometabolism and lipid metabolism.
Publisher DOI
PubMed ID
41265582
Abstract
The ketogenic diet (KD) has shown therapeutic potential for epilepsy, neuroprotective effects, and, more recently, metabolic complications. In this study, we explored the impact of the KD on the promotion of ketometabolism and the improvement of dyslipidemia. To this end, we investigated the outcomes of two different diets, eucaloric KD and low-calorie diet (LCD), on ketogenesis, circulating intact lipids, bile acids, and neuro and pancreatic peptides. Based on our results, the concentration of ketone bodies, namely 3-hydroxybutyric acid, increased significantly by an average of 10 and 2 times for KD and LCD, respectively. Additionally, the concentration of several triglyceride (TAG) species decreased up to 98.3% and 99.1% for KD and LCD, respectively, while these reductions were only significant for LCD. Moreover, our results showed that three days of KD led to an increase in the baseline concentration of pancreatic polypeptide 3-36, which suggests that short-term KD has the potential to suppress the appetite. Finally, no significant change in the baseline and kinetic postprandial concentration of bile acid species was observed during the KD. In conclusion, our findings suggest that the ketogenic diet, being less restrictive than the low-calorie diet, has a greater impact on ketometabolism. However, while KD reduces TAG species, this reduction is not statistically significant, unlike the significant decrease observed with LCD.
Date Issued
2026-03
Publication Type
Article
Subject(s)
Subjects
Calorie restriction
•
Dietary intervention
•
Dyslipidemia
•
Ketogenesis
•
Ketometabolism
Language(s)
en
Author(s)
Maurer, Jonathan | |
Additional Credits
Journal
The Journal of Nutritional Biochemistry
Publisher
Elsevier
ISSN
1873-4847
0955-2863
Access(Rights)
open.access