Publication: pN1 but not pN0/N2 predicts survival benefits of prophylactic cranial irradiation in small-cell lung cancer patients after surgery.
cris.virtual.author-orcid | 0000-0002-8732-5910 | |
cris.virtualsource.author-orcid | f92a6b6d-2f0d-419c-977b-296ec58d16c9 | |
cris.virtualsource.author-orcid | 4497fd2b-91cc-47e0-b388-c8c3326d5319 | |
cris.virtualsource.author-orcid | a4a688fa-027d-4b45-9d4a-4a47d8ac0001 | |
datacite.rights | open.access | |
dc.contributor.author | Yang, Haitang | |
dc.contributor.author | Al-Hurani, Mohammad | |
dc.contributor.author | Xu, Jianlin | |
dc.contributor.author | Fan, Liwen | |
dc.contributor.author | Schmid, Ralph | |
dc.contributor.author | Zhao, Heng | |
dc.contributor.author | Yao, Feng | |
dc.date.accessioned | 2024-09-21T16:04:15Z | |
dc.date.available | 2024-09-21T16:04:15Z | |
dc.date.issued | 2021-04 | |
dc.description.abstract | Background Prophylactic cranial irradiation has been shown to reduce brain metastases and provide survival benefits in small-cell lung cancer (SCLC). However, its role in limited-stage SCLC patients after surgery remains unclear. Further, it is unknown whether the effect of prophylactic cranial irradiation is generalizable in these patients with different pathological nodal (N0-N2) stages, a state indicating the presence of tumor metastases. Methods We combined data from a single medical center and Surveillance, Epidemiology, and End Results database. Propensity score matching analyses were performed (1:2) to evaluate the role of prophylactic cranial irradiation in SCLC patients after surgery. Cox proportional hazards regression model was used to identify predictors of survival. Results 124 (18.7%) out of 664 surgically-treated SCLC patients received prophylactic cranial irradiation treatment. Within the entire cohort, multivariate Cox regression analysis identified dataset source, age, pathological T and N stages, adjuvant chemotherapy, resection type, and histology as independent prognostic factors for overall survival. Prophylactic cranial irradiation appeared to be associated with a better overall survival, but the difference is marginally significant (P=0.063). Further, we stratified patients based on the pathological N0-N2 stages using propensity score matching analyses, which showed that prophylactic cranial irradiation treatment was superior to non-prophylactic cranial irradiation treatment for surgically-treated SCLC patients with N1 stage only (univariate analysis: P=0.026; multivariate Cox: P=0.004), but not N0/N2 stage (univariate analysis: P=0.65 and P=0.28, respectively; multivariate Cox: P=0.99 and P=0.35, respectively). Conclusions Prophylactic cranial irradiation provides survival benefits for SCLC patients with pN1 after surgery but not with pathological N0/N2 stage. Our findings may provide helpful stratifications for clinical decision-making of prophylactic cranial irradiation intervention in SCLC patients. | |
dc.description.sponsorship | Department for BioMedical Research (DBMR) | |
dc.description.sponsorship | Universitätsklinik für Thoraxchirurgie | |
dc.description.sponsorship | Department for BioMedical Research, Forschungsgruppe Thoraxchirurgie | |
dc.identifier.doi | 10.48350/157716 | |
dc.identifier.pmid | 33987260 | |
dc.identifier.publisherDOI | 10.21037/atm-20-6984 | |
dc.identifier.uri | https://boris-portal.unibe.ch/handle/20.500.12422/45709 | |
dc.language.iso | en | |
dc.publisher | AME Publishing Company | |
dc.relation.ispartof | Annals of translational medicine | |
dc.relation.issn | 2305-5839 | |
dc.relation.organization | DCD5A442BE57E17DE0405C82790C4DE2 | |
dc.relation.organization | DCD5A442BAD7E17DE0405C82790C4DE2 | |
dc.relation.organization | DCD5A442BD18E17DE0405C82790C4DE2 | |
dc.subject | Small-cell lung cancer (SCLC) nodal metastasis prophylactic cranial irradiation surgery | |
dc.subject.ddc | 600 - Technology::610 - Medicine & health | |
dc.title | pN1 but not pN0/N2 predicts survival benefits of prophylactic cranial irradiation in small-cell lung cancer patients after surgery. | |
dc.type | article | |
dspace.entity.type | Publication | |
oaire.citation.issue | 7 | |
oaire.citation.startPage | 562 | |
oaire.citation.volume | 9 | |
oairecerif.author.affiliation | Department for BioMedical Research, Forschungsgruppe Thoraxchirurgie | |
oairecerif.author.affiliation | Department for BioMedical Research (DBMR) | |
oairecerif.author.affiliation | Universitätsklinik für Thoraxchirurgie | |
oairecerif.author.affiliation2 | Universitätsklinik für Thoraxchirurgie | |
oairecerif.author.affiliation2 | Department for BioMedical Research, Forschungsgruppe Thoraxchirurgie | |
oairecerif.author.affiliation2 | Department for BioMedical Research, Forschungsgruppe Thoraxchirurgie | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.date.licenseChanged | 2021-07-27 19:52:44 | |
unibe.description.ispublished | pub | |
unibe.eprints.legacyId | 157716 | |
unibe.refereed | true | |
unibe.subtype.article | journal |
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